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Understanding second cancers after treatment for cancer in childhood
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Around 1,900 children are diagnosed with cancer every year in the UK. Treatment has improved greatly over the past few decades, and most children now survive their cancer. There are now more than 35,000 people in the UK who have survived cancer diagnosed in childhood.
Although survival has improved, some people develop health problems many years after treatment. These are often called long-term or late effects. One important and serious late effect is a second cancer. This means a new and different cancer that develops years, or sometimes decades, after treatment for the first cancer. Some studies suggest that around 15–20% of cancers are second cancers.
Radiotherapy is an important treatment for many childhood cancers, but it can also increase the risk of second cancers later in life. Modern radiotherapy techniques have changed over time, with great improvements designed to reduce long-term side effects. However, we still need better evidence about how different radiotherapy treatments, and combinations of radiotherapy and chemotherapy, affect the long-term risk of second cancers.
To help support better follow-up care, screening, and information for patients and families, this research will focus on childhood cancer patients (diagnosed before age 18 years) in England using national NHS health records to improve understanding of long-term risks after childhood cancer treatment. By linking several national datasets, we can examine:
• How treatments have changed over time
• How radiotherapy affects the risk of second cancers
• How different combinations of radiotherapy and chemotherapy affect the risk of second cancers
How can you get involved?
Please fill out the survey below if you had childhood cancer or if you are a parent/ carer of someone who had childhood cancer. The aim of this survey is to understand your views on the importance and relevance of this research. Your feedback will directly help shape how this project is developed and ensure it reflects what matters most to patients and families. Within the survey you can also indicate if you would like to be involved in the next stages of this work.
Around 1,900 children are diagnosed with cancer every year in the UK. Treatment has improved greatly over the past few decades, and most children now survive their cancer. There are now more than 35,000 people in the UK who have survived cancer diagnosed in childhood.
Although survival has improved, some people develop health problems many years after treatment. These are often called long-term or late effects. One important and serious late effect is a second cancer. This means a new and different cancer that develops years, or sometimes decades, after treatment for the first cancer. Some studies suggest that around 15–20% of cancers are second cancers.
Radiotherapy is an important treatment for many childhood cancers, but it can also increase the risk of second cancers later in life. Modern radiotherapy techniques have changed over time, with great improvements designed to reduce long-term side effects. However, we still need better evidence about how different radiotherapy treatments, and combinations of radiotherapy and chemotherapy, affect the long-term risk of second cancers.
To help support better follow-up care, screening, and information for patients and families, this research will focus on childhood cancer patients (diagnosed before age 18 years) in England using national NHS health records to improve understanding of long-term risks after childhood cancer treatment. By linking several national datasets, we can examine:
• How treatments have changed over time
• How radiotherapy affects the risk of second cancers
• How different combinations of radiotherapy and chemotherapy affect the risk of second cancers
How can you get involved?
Please fill out the survey below if you had childhood cancer or if you are a parent/ carer of someone who had childhood cancer. The aim of this survey is to understand your views on the importance and relevance of this research. Your feedback will directly help shape how this project is developed and ensure it reflects what matters most to patients and families. Within the survey you can also indicate if you would like to be involved in the next stages of this work.
