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Helping surgeons see tumours more clearly during surgery
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Surgery is the main treatment for many people with gastrointestinal stromal tumours (GIST) and other abdominal sarcomas. A key aim of surgery is to remove the tumour completely. However, even when surgeons carefully plan an operation using scans, it can sometimes be difficult to clearly see the exact edges of the tumour during surgery.
This project is exploring whether a safe fluorescent dye called indocyanine green (ICG) could help surgeons see tumours more clearly during an operation.
ICG has been used safely in medicine for many years and is already used in several types of surgery. In this study, the dye would be given through a vein 12–24 hours before the operation. We believe that during this time the dye may collect in the tumour tissue more than in surrounding healthy tissue.
During the operation, surgeons would use a special near-infrared camera that can detect the dye. If the tumour absorbs the dye, it may appear brighter than the surrounding tissue, which could help the surgical team identify the tumour edges more clearly.
This study is a small feasibility study involving around 15 patients undergoing surgery for abdominal sarcoma or GIST. The aim is to see whether this technique works, its safety level, and if it can be used easily during surgery.
If the technique proves promising, it could lead to a larger future study looking at whether this approach helps reduce the chances of tumour tissue being accidentally left behind during surgery.
How can you get involved?
As part of this study patients would need to come to hospital the day before their surgery to receive the dye. Please share any thoughts on how you would feel about that, and what logistical help could be provided to facilitate this.
Surgery is the main treatment for many people with gastrointestinal stromal tumours (GIST) and other abdominal sarcomas. A key aim of surgery is to remove the tumour completely. However, even when surgeons carefully plan an operation using scans, it can sometimes be difficult to clearly see the exact edges of the tumour during surgery.
This project is exploring whether a safe fluorescent dye called indocyanine green (ICG) could help surgeons see tumours more clearly during an operation.
ICG has been used safely in medicine for many years and is already used in several types of surgery. In this study, the dye would be given through a vein 12–24 hours before the operation. We believe that during this time the dye may collect in the tumour tissue more than in surrounding healthy tissue.
During the operation, surgeons would use a special near-infrared camera that can detect the dye. If the tumour absorbs the dye, it may appear brighter than the surrounding tissue, which could help the surgical team identify the tumour edges more clearly.
This study is a small feasibility study involving around 15 patients undergoing surgery for abdominal sarcoma or GIST. The aim is to see whether this technique works, its safety level, and if it can be used easily during surgery.
If the technique proves promising, it could lead to a larger future study looking at whether this approach helps reduce the chances of tumour tissue being accidentally left behind during surgery.
How can you get involved?
As part of this study patients would need to come to hospital the day before their surgery to receive the dye. Please share any thoughts on how you would feel about that, and what logistical help could be provided to facilitate this.
A GIST is a rare type of sarcoma found in the wall of the digestive system. It is most often found in the stomach, but it can also grow in other parts. A soft tissue sarcoma is a type of cancer.